Drug Name: | Amphotericin B |
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Drug Class: | Antifungal |
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Mechanism of Action: | - Binds to ergosterol in fungal cell membranes, causing membrane permeability and cell death
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Use: | - Treatment of severe systemic fungal infections, such as invasive candidiasis, aspergillosis, and cryptococcosis
- Prophylaxis in immunocompromised patients at high risk of fungal infections
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Side Effects: | - Nephrotoxicity
- Infusion-related reactions (fever, chills, hypotension)
- Electrolyte imbalances (hypokalemia, hypomagnesemia)
- Anemia
- Thrombophlebitis
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Contraindications: | - Hypersensitivity to amphotericin B or any component of the formulation
- Severe renal impairment
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Specialty: | - Infectious Disease
- Hematology
- Oncology
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